Howard E F, Thompson Y G, Lapp C A, Greenbaum L M
Department of Cell and Molecular Biology, School of Graduate Studies, Medical College of Georgia, Augusta 30912-2100.
Life Sci. 1990;46(6):411-7. doi: 10.1016/0024-3205(90)90084-5.
When inflammation is induced in rats following injection of Freund's complete adjuvant, steady state levels of T-I and T-II kininogen mRNAs increase markedly as do plasma levels of T-I and T-II kininogens. When rats are additionally treated with dexamethasone, T-I and T-II steady state mRNA levels and plasma levels of T-kininogens are reduced. The results suggest that dexamethasone may affect the magnitude of T-kininogen gene induction caused by inflammation.
当给大鼠注射弗氏完全佐剂诱导炎症后，T-I和T-II激肽原mRNA的稳态水平显著升高，T-I和T-II激肽原的血浆水平也升高。当给大鼠额外使用地塞米松治疗时，T-I和T-II稳态mRNA水平以及T-激肽原的血浆水平降低。结果表明，地塞米松可能会影响由炎症引起的T-激肽原基因诱导的程度。
