Barlas A, Okamoto H, Greenbaum L M
Adv Exp Med Biol. 1986;198 Pt A:61-8. doi: 10.1007/978-1-4684-5143-6_9.
Studies have been carried out to clarify which component of plasma kininogen in rats increased in the inflammatory condition induced by an injection of Freund's complete adjuvant. Plasma T-kininogen, which was measured by assaying the amount of T-kinin liberated by trypsin treatment, remarkably increased in parallel with the severity of paw swelling following the intradermal injection of adjuvant into the rat hindpaw. Treatment with indomethacin or dexamethasone following an injection of adjuvant suppressed the increase in T-kininogen level as well as the development of paw swelling in rats. These results indicate that T-kininogen, the newly found precursor of T-kinin, is the main component of plasma kininogen which responds to the inflammatory stimulus in adjuvant arthritis.
已经开展了多项研究，以阐明在注射弗氏完全佐剂诱导的炎症状态下，大鼠血浆激肽原的哪个成分会增加。通过测定经胰蛋白酶处理后释放的T-激肽量来测量的血浆T-激肽原，在向大鼠后爪皮内注射佐剂后，与爪肿胀的严重程度平行显著增加。注射佐剂后用吲哚美辛或地塞米松治疗可抑制大鼠T-激肽原水平的升高以及爪肿胀的发展。这些结果表明，新发现的T-激肽前体T-激肽原是血浆激肽原中对佐剂性关节炎炎症刺激产生反应的主要成分。
