Rosenberg H C, Tietz E I, Zhang H, Chiu T H
Department of Pharmacology, Medical College of Ohio, Toledo 43699.
Life Sci. 1990;46(7):519-25. doi: 10.1016/0024-3205(90)90008-f.
The spontaneous activity of neurons in the pars reticulata of substantia nigra (SNpr) was studied in chloral hydrate anesthetized rats. As a function of dose, intravenous diazepam decreased, and methyl-beta-carboline-3-carboxylate (beta CCM) increased discharge frequency. Two days after terminating a one week treatment with flurazepam (FZP), both diazepam and beta CCM showed decreased ability to alter SNpr neuronal activity. Neither residual FZP nor down-regulation of benzodiazepine receptors can account for these results. In contrast, behavioral testing revealed no change in the ability of i.v. beta CCM to cause convulsions, suggesting that sites other than the SNpr are of prime importance in expressing the convulsant actions of systemically injected beta CCM.
在水合氯醛麻醉的大鼠中，研究了黑质网状部（SNpr）神经元的自发活动。静脉注射地西泮可使放电频率随剂量增加而降低，而甲基-β-咔啉-3-羧酸酯（βCCM）则使其增加。在终止氟西泮（FZP）一周治疗后的两天，地西泮和βCCM改变SNpr神经元活动的能力均下降。残留的FZP和苯二氮䓬受体下调均不能解释这些结果。相反，行为测试显示静脉注射βCCM引起惊厥的能力没有变化，这表明除SNpr外的其他部位在表达全身注射βCCM的惊厥作用中至关重要。
