Tyma J L, Rosenberg H C, Tietz E I, Chiu T H
Department of Pharmacology, Medical College of Ohio, Toledo 43699.
Brain Res. 1988 Jun 21;453(1-2):344-8. doi: 10.1016/0006-8993(88)90175-8.
The effect of a benzodiazepine, flurazepam, on the spontaneous activity of neurons in the pars reticulata of the substantia nigra was studied in chloral hydrate anesthetized rats. Flurazepam produced a dose-related suppression of neuronal activity. In rats that were chronically treated with flurazepam, tolerance to flurazepam was present after 7 and 28 days, but not after only 3 days of treatment. Tolerance persisted at least 2, but not 7 days after 4 weeks of chronic treatment.
