Department of Anatomy, Kasturba Medical College, Mangalore, Manipal University, 575 001 India.
Pharmacol Biochem Behav. 2013 Jan;103(3):520-5. doi: 10.1016/j.pbb.2012.09.012. Epub 2012 Oct 5.
Resveratrol, an active ingredient of red wine extracts, has been shown to exhibit neuroprotective effects in several experimental models. Hence in the present study, the protective effects of resveratrol on cognitive deficits induced by prenatal stress were evaluated in offspring, and the possible involvement of Na(+), K(+)-ATPase in learning deficits were explored. Pregnant rats were subjected to restraint stress during early or late gestational period. Another set of rats received resveratrol during the entire gestational period along with early or late gestational stress. The study parameters included various behavioral tests like open field test and Morris water maze test. At the end of the behavioral tests (on 40th postnatal day), the offspring were sacrificed, and their brain homogenate was subjected to Na(+), K(+)-ATPase estimation. Early and late gestational stress affected spatial learning and memory and prenatal resveratrol has reversed these cognitive deficits. The Na(+), K(+)-ATPase activity in the offspring brain homogenate was reduced in the late gestational stress group; however prenatal resveratrol treatment has not affected this activity. These data suggest the neuroprotective efficacy of resveratrol against prenatal stress induced cognitive impairment. Though late gestational stress involves Na(+), K(+)-ATPase activity in rat brain homogenate, this would not be the primary cause in prenatal stress-induced cognitive dysfunction.
白藜芦醇是红酒提取物中的一种活性成分，已被证明在几种实验模型中具有神经保护作用。因此，本研究评估了白藜芦醇对产前应激引起的子代认知缺陷的保护作用，并探讨了 Na(+)、K(+) -ATP 酶在学习缺陷中的可能参与作用。妊娠大鼠在妊娠早期或晚期接受束缚应激。另一组大鼠在整个妊娠期以及早期或晚期妊娠应激期间接受白藜芦醇治疗。研究参数包括各种行为测试，如旷场试验和 Morris 水迷宫试验。在行为测试结束时（第 40 天），处死子代，其脑匀浆用于测定 Na(+)、K(+) -ATP 酶。早期和晚期的妊娠期应激影响空间学习和记忆，而产前白藜芦醇逆转了这些认知缺陷。子代脑匀浆中的 Na(+)、K(+) -ATP 酶活性在晚期妊娠应激组中降低；然而，产前白藜芦醇处理并未影响这种活性。这些数据表明白藜芦醇对产前应激引起的认知障碍具有神经保护作用。尽管晚期妊娠应激涉及大鼠脑匀浆中的 Na(+)、K(+) -ATP 酶活性，但这不是产前应激引起的认知功能障碍的主要原因。
