Bus James S
The Dow Chemical Company, Midland, Michigan, USA.
Curr Protoc Toxicol. 2007 Feb;Chapter 19:Unit19.2. doi: 10.1002/0471141755.tx1902s31.
The modern era of chemistry has resulted in dramatic improvements in the overall human condition. In addition to new pharmaceuticals, modern chemistry has brought with it enormous health and social benefits Introduction of chemistry-based technologies, however, has also been clearly associated with potential human health risks. The dramatic increase in pharmaceutical and chemical technologies in the post World War II era, coupled with associated examples of demonstrated human toxicity, led to development and application of an expanded and standardized battery of animal and other toxicity tests designed to characterize the potential hazards and risks associated with chemical exposures. This unit discusses the current approach to industrial chemical and pesticide toxicity testing.
化学的现代时代已使人类的整体状况得到了显著改善。除了新型药物外，现代化学还带来了巨大的健康和社会效益。然而，基于化学的技术的引入也显然与潜在的人类健康风险相关联。第二次世界大战后，制药和化学技术急剧增加，再加上已证实的对人类有毒性的相关实例，促使人们开发并应用了一系列经过扩展和标准化的动物及其他毒性测试，旨在确定与化学物质接触相关的潜在危害和风险。本单元将讨论当前工业化学品和农药毒性测试的方法。
