Li Albert P
In Vitro ADMET Laboratories, Columbia, Maryland, USA.
Curr Protoc Toxicol. 2007;Chapter 4:Unit 4.25. doi: 10.1002/0471140856.tx0425s33.
Adverse drug-drug interactions represent a major challenge for the pharmaceutical industry. Recently, in vitro approaches for the evaluation of metabolism-related drug-drug interactions have been developed. These in vitro approaches are found to be useful in the assessment of clinical drug-drug interaction potential of new chemical entities and to aid the understanding of clinically significant drug-drug interactions observed with existing drugs. The general methods for the evaluation of drug-drug interactions using in vitro, human-based experimental systems are described and critically reviewed.
药物不良反应相互作用是制药行业面临的一项重大挑战。最近，已开发出用于评估代谢相关药物相互作用的体外方法。这些体外方法被发现可用于评估新化学实体的临床药物相互作用潜力，并有助于理解现有药物观察到的具有临床意义的药物相互作用。本文描述并批判性地综述了使用体外基于人体的实验系统评估药物相互作用的一般方法。
