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Can physiology zap therapeutic sweet spots in hypertension?

作者信息

Joyner Michael J

出版信息

Hypertension. 2012 Dec;60(6):1385-6. doi: 10.1161/HYPERTENSIONAHA.112.202754. Epub 2012 Oct 8.

DOI:10.1161/HYPERTENSIONAHA.112.202754
PMID:23045467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3499672/
Abstract
摘要

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Can physiology zap therapeutic sweet spots in hypertension?生理学能精准定位高血压的治疗靶点吗？
Hypertension. 2012 Dec;60(6):1385-6. doi: 10.1161/HYPERTENSIONAHA.112.202754. Epub 2012 Oct 8.
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Response to catheter-based renal nerve ablation and centrally generated sympathetic activity in difficult-to- control hypertensive patients.难治性高血压患者对基于导管的肾神经消融术及中枢性交感神经活动的反应
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Catheter-based renal nerve ablation and centrally generated sympathetic activity in difficult-to-control hypertensive patients: prospective case series.基于导管的肾神经消融与难治性高血压患者中枢产生的交感神经活动：前瞻性病例系列研究
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Response to catheter-based renal nerve ablation and centrally generated sympathetic activity in difficult-to- control hypertensive patients: prospective case series.难治性高血压患者对基于导管的肾神经消融术的反应及中枢产生的交感神经活动：前瞻性病例系列研究
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Control of salt and volume retention cannot be ruled out as a mechanism underlying the blood pressure-lowering effect of renal denervation.不能排除控制盐和容量潴留是肾去神经支配降压作用的潜在机制。
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Catheter-based renal nerve ablation and centrally generated sympathetic activity in difficult-to-control hypertensive patients: prospective case series.经导管肾脏神经消融术与难以控制的高血压患者中枢交感神经活动：前瞻性病例系列研究。
Hypertension. 2012 Dec;60(6):1485-90. doi: 10.1161/HYPERTENSIONAHA.112.201186. Epub 2012 Oct 8.
2
Minimally invasive system for baroreflex activation therapy chronically lowers blood pressure with pacemaker-like safety profile: results from the Barostim neo trial.用于压力反射激活疗法的微创系统可长期降低血压，具有类似起搏器的安全性：Barostim neo试验结果
J Am Soc Hypertens. 2012 Jul-Aug;6(4):270-6. doi: 10.1016/j.jash.2012.04.004. Epub 2012 Jun 12.
3
Reengineering translational science: the time is right.重新设计转化科学：时机已到。
Sci Transl Med. 2011 Jul 6;3(90):90cm17. doi: 10.1126/scitranslmed.3002747.
4
Why physiology matters in medicine.生理学在医学中为何重要。
Physiology (Bethesda). 2011 Apr;26(2):72-5. doi: 10.1152/physiol.00003.2011.
5
Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial.治疗抵抗性高血压患者的肾脏去神经支配（Symplicity HTN-2 试验）：一项随机对照试验。
Lancet. 2010 Dec 4;376(9756):1903-9. doi: 10.1016/S0140-6736(10)62039-9. Epub 2010 Nov 17.
6
Confusion about the appropriate use of erythropoiesis-stimulating agents in patients undergoing maintenance dialysis.
Semin Dial. 2010 Sep-Oct;23(5):486-91. doi: 10.1111/j.1525-139x.2010.00768.x.
7
Sympathetic nervous system and blood pressure in humans: individualized patterns of regulation and their implications.人类的交感神经系统与血压：调节的个体化模式及其影响
Hypertension. 2010 Jul;56(1):10-6. doi: 10.1161/HYPERTENSIONAHA.109.140186. Epub 2010 May 24.
8
Reengineering the national clinical and translational research enterprise: the strategic plan of the National Clinical and Translational Science Awards Consortium.国家临床与转化研究企业的重塑：国家临床与转化科学奖联盟的战略计划。
Acad Med. 2010 Mar;85(3):463-9. doi: 10.1097/ACM.0b013e3181ccc877.
9
Translational medicine: the antihypertensive effect of renal denervation.转化医学：肾脏去神经支配的降压作用。
Am J Physiol Regul Integr Comp Physiol. 2010 Feb;298(2):R245-53. doi: 10.1152/ajpregu.00647.2009. Epub 2009 Dec 2.
10
Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research.难治性高血压：诊断、评估与治疗。美国心脏协会高血压研究理事会专业教育委员会的科学声明。
Hypertension. 2008 Jun;51(6):1403-19. doi: 10.1161/HYPERTENSIONAHA.108.189141. Epub 2008 Apr 7.