Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Ann N Y Acad Sci. 2012 Oct;1269:26-33. doi: 10.1111/j.1749-6632.2012.06697.x.
Since it was first identified, thymosin alpha 1 (Tα1) has been characterized to have pleiotropic effects on several pathological conditions, in particular as a modulator of immune response and inflammation. Several properties exerted by Tα1 may be attributable to a direct action on lymphoid cells. Tα1 has been shown to exert an immune modulatory activity on both T cell and natural killer cell maturation and to have an effect on functions of mature lymphocytes, including stimulating cytokine production and cytotoxic T lymphocyte-mediated cytotoxic responses. In previous studies we have shown that Tα1 increases the expression of major histocompatibility complex class I surface molecules in murine and human tumor cell lines and in primary cultures of human macrophages. In the present paper, we describe preliminary data indicating that Tα1 is also capable of increasing the expression of tumor antigens in both experimental and human tumor cell lines. This effect, which is exerted at the level of the target tumor cells, represents an additional factor increasing the antitumor activity of Tα1.
自从胸腺肽 α1（Tα1）被首次鉴定以来，它已被证明对多种病理状况具有多种作用，特别是作为免疫反应和炎症的调节剂。Tα1 发挥的几种特性可能归因于对淋巴细胞的直接作用。Tα1 已被证明对 T 细胞和自然杀伤细胞的成熟具有免疫调节活性，并对成熟淋巴细胞的功能具有影响，包括刺激细胞因子的产生和细胞毒性 T 淋巴细胞介导的细胞毒性反应。在以前的研究中，我们已经表明 Tα1 增加了小鼠和人肿瘤细胞系以及人巨噬细胞原代培养物中主要组织相容性复合体 I 表面分子的表达。在本文中，我们描述了初步数据，表明 Tα1 还能够增加实验和人肿瘤细胞系中肿瘤抗原的表达。这种作用发生在靶肿瘤细胞水平，代表了增加 Tα1 抗肿瘤活性的另一个因素。
