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健康与疾病中的感觉神经肽。关于1989年佛罗伦萨会议的报告

Sensory neuropeptides in health and disease. Conference report on Florence '89.

作者信息

Manzini S, Geppetti P, Maggi C A

机构信息

Istituto Farmacobiologico Malesci, Research Laboratories, Florence, Italy.

出版信息

Neurosci Lett. 1990 Jan 1;108(1-2):237-40. doi: 10.1016/0304-3940(90)90737-t.

DOI:10.1016/0304-3940(90)90737-t
PMID:2304634
Abstract

A workshop (chaired by F. Lembeck, Graz) was held in Florence on 1 and 2 June 1989 with the aims to present and discuss the state of the art of research on sensory neuropeptides, i.e. those peptides demonstrated to be coded and synthetized in and released from sensory neurons. The meeting was therefore, particularly focused on tachykinins (substance P, neurokinin A and B) and calcitonin gene-related peptide (CGRP) and on the use of capsaicin as a pharmacological tool for studying the function of the related neurons. Particular relevance was paid to the biological effects and pathophysiological role(s) of sensory neuropeptides peripherally released ('efferent' function) from capsaicin-sensitive primary afferents.

摘要

1989年6月1日至2日,在佛罗伦萨举办了一场研讨会(由格拉茨的F. 伦贝克主持),旨在展示和讨论感觉神经肽的研究现状,即那些已被证明在感觉神经元中编码、合成并释放的肽。因此,本次会议特别聚焦于速激肽(P物质、神经激肽A和B)和降钙素基因相关肽(CGRP),以及辣椒素作为研究相关神经元功能的药理学工具的应用。特别关注了辣椒素敏感的初级传入神经外周释放的感觉神经肽的生物学效应和病理生理作用(“传出”功能)。

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