Institute of Neurosciences and Psychology, School of Medicine, University of Glasgow, Glasgow, UK.
J Cereb Blood Flow Metab. 2012 Dec;32(12):2114-7. doi: 10.1038/jcbfm.2012.142. Epub 2012 Oct 10.
Hyperoxia during T2*-weighted magnetic resonance imaging (oxygen challenge imaging (OCI)) causes T2*-weighted signal change that is dependent on cerebral blood volume (CBV) and oxygen extraction fraction (OEF). Crossed cerebellar diaschisis (CCD), where CBV is reduced but OEF is maintained, may be used to understand the relative contributions of OEF and CBV to OCI results. In subjects with large hemispheric strokes, OCI showed reduced signal change in the contralesional cerebellum (P=0.027, n=12). This was associated with reduced CBV in contralesional cerebellum (P=0.039, n=9). CCD may be a useful model to determine the relative contribution of CBV to signal change measured by OCI.
在 T2*-加权磁共振成像（氧挑战成像（OCI））期间的高氧会导致 T2*-加权信号变化，该变化取决于脑血容量（CBV）和氧摄取分数（OEF）。交叉小脑失联络（CCD）中，CBV 降低但 OEF 保持不变，可用于了解 OEF 和 CBV 对 OCI 结果的相对贡献。在患有大半球性中风的患者中，OCI 显示对侧小脑的信号变化减少（P=0.027，n=12）。这与对侧小脑的 CBV 减少相关（P=0.039，n=9）。CCD 可能是一种有用的模型，用于确定 OCI 测量的信号变化中 CBV 的相对贡献。
