Grupo de Química Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
Nat Prod Rep. 2012 Dec;29(12):1463-79. doi: 10.1039/c2np20060k. Epub 2012 Oct 9.
This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids (PTs) are provided.
本综述重点介绍了天然和半合成熊果酸型三萜作为设计多靶点生物活性化合物的候选物的潜力,特别关注其抗癌作用。简要说明了天然存在的五环三萜(PTs)主要类别的生物合成、来源和一般生物学效应。