Key Lab of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (PUMC), Ministry of Education, Chinese Academy of Medical Science, Beijing 100050, China.
Curr Top Med Chem. 2009;9(16):1581-96. doi: 10.2174/156802609789909821.
Pentacyclic triterpenoids exert their antitumor activity through different mechanisms, one of which is apoptosis induction. Although there are many reports on the apoptosis inducing activity of pentacyclic triterpenoids, a systematic survey and discussion on their structure-activity relationships (SARs) is still lacking. In this review, we summarized such activity of oleanane, ursane and lupane type triterpenoids, the most abundant pentacyclic triterpene prototypes in plants. Their structural characteristics responsible for the activity are also discussed, in order to unravel their SARs for the apoptotic induction and benefit further investigations on the antitumor triterpenoids.
五环三萜通过不同的机制发挥其抗肿瘤活性，其中之一是诱导细胞凋亡。尽管已有许多关于五环三萜诱导细胞凋亡活性的报道，但对其构效关系（SARs）的系统调查和讨论仍然缺乏。在这篇综述中，我们总结了植物中最丰富的五环三萜原型齐墩果烷型、熊果烷型和羽扇豆烷型三萜的这种活性。还讨论了它们负责这种活性的结构特征，以便揭示它们在诱导细胞凋亡方面的 SARs，从而有利于对抗肿瘤三萜的进一步研究。
