Medical Research Unit, Albert Schweitzer Hospital Lambaréné, Lambaréné, Gabon.
Epidemiol Infect. 2013 Aug;141(8):1717-20. doi: 10.1017/S0950268812002270. Epub 2012 Oct 10.
Children with sickle cell anaemia (SCA) might carry hospital-associated bacterial lineages due to frequent hospital stays and antibiotic treatments. In this study we compared Staphylococcus aureus from SCA patients (n=73) and healthy children (n=143) in a cross-sectional study in Gabon. S. aureus carriage did not differ between children with SCA (n=34, 46∙6%) and controls matched for age, residence and sex (n=67, 46∙9%). Both groups shared similar S. aureus genotypes. This finding points towards a transmission of S. aureus between both groups in the community. We conclude that resistance rates from population-based studies with healthy participants could therefore also be used to guide treatment and prophylaxis of endogenous infections in children with SCA despite a different selection pressure.
镰状细胞贫血（SCA）患儿由于频繁住院和抗生素治疗，可能携带医院相关的细菌谱系。在这项研究中，我们在加蓬进行了一项横断面研究，比较了 SCA 患儿（n=73）和健康儿童（n=143）的金黄色葡萄球菌。SCA 患儿（n=34，46.6%）与年龄、居住地和性别相匹配的对照组（n=67，46.9%）之间的金黄色葡萄球菌携带率无差异。两组共享相似的金黄色葡萄球菌基因型。这一发现表明金黄色葡萄球菌在社区中两组之间存在传播。我们得出结论，尽管存在不同的选择压力，但来自健康参与者的基于人群的研究中的耐药率也可用于指导 SCA 患儿内源性感染的治疗和预防。
