定植于镰状细胞贫血症患儿和健康对照者的金黄色葡萄球菌的克隆结构。
Clonal structure of Staphylococcus aureus colonizing children with sickle cell anaemia and healthy controls.
机构信息
Medical Research Unit, Albert Schweitzer Hospital Lambaréné, Lambaréné, Gabon.
出版信息
Epidemiol Infect. 2013 Aug;141(8):1717-20. doi: 10.1017/S0950268812002270. Epub 2012 Oct 10.
Abstract
Children with sickle cell anaemia (SCA) might carry hospital-associated bacterial lineages due to frequent hospital stays and antibiotic treatments. In this study we compared Staphylococcus aureus from SCA patients (n=73) and healthy children (n=143) in a cross-sectional study in Gabon. S. aureus carriage did not differ between children with SCA (n=34, 46∙6%) and controls matched for age, residence and sex (n=67, 46∙9%). Both groups shared similar S. aureus genotypes. This finding points towards a transmission of S. aureus between both groups in the community. We conclude that resistance rates from population-based studies with healthy participants could therefore also be used to guide treatment and prophylaxis of endogenous infections in children with SCA despite a different selection pressure.
摘要
镰状细胞贫血（SCA）患儿由于频繁住院和抗生素治疗，可能携带医院相关的细菌谱系。在这项研究中，我们在加蓬进行了一项横断面研究，比较了 SCA 患儿（n=73）和健康儿童（n=143）的金黄色葡萄球菌。SCA 患儿（n=34，46.6%）与年龄、居住地和性别相匹配的对照组（n=67，46.9%）之间的金黄色葡萄球菌携带率无差异。两组共享相似的金黄色葡萄球菌基因型。这一发现表明金黄色葡萄球菌在社区中两组之间存在传播。我们得出结论，尽管存在不同的选择压力，但来自健康参与者的基于人群的研究中的耐药率也可用于指导 SCA 患儿内源性感染的治疗和预防。
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