无金属条件下 Brønsted 酸促进的 N-烯基砜亚胺的分子内氨羟化反应。
Brønsted acid-assisted intramolecular aminohydroxylation of N-alkenylsulfonamides under heavy metal-free conditions.
机构信息
Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan.
出版信息
J Org Chem. 2012 Nov 2;77(21):9846-51. doi: 10.1021/jo301523a. Epub 2012 Oct 18.
PMID:23050809
Abstract
The intramolecular aminohydroxylation of N-alkenylsulfonamides proceeded under heavy metal-free conditions to give substituted prolinol derivatives in high yields. Oxone activated by catalytic Brønsted acid worked well as an electrophilic oxidant for this reaction.
摘要
在无金属条件下，通过 N-烯基砜亚胺的分子内氨羟化反应，高产率地得到取代脯氨醇衍生物。相转移催化剂作用下的 Oxone 可以有效地作为该反应的亲电氧化剂。
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