University of Florida, Gainesville, FL, USA.
Asian J Psychiatr. 2010 Mar;3(1):35-40. doi: 10.1016/j.ajp.2010.01.002. Epub 2010 Mar 4.
One critical skill in the practice of evidence-based medicine is the ability to correctly interpret and apply findings of a study relevant to the clinical question needing to be answered. In this paper, we outline an approach to asking the clinical question in a form answerable by a research study and then finding the most relevant study. We next define the two steps in the process of applying a study's findings towards making a treatment decision and discuss the threats to validity approach. We summarize concepts of statistical conclusion validity, internal validity, construct validity, and external validity. We illustrate the method utilizing a clinical vignette that requires choice of an antipsychotic agent. We discuss the results of Clinical Antipsychotic Trial of Intervention Effectiveness (CATIE) in schizophrenia and consider the threats to the different forms of validity in CATIE.
循证医学实践中的一项关键技能是能够正确解释和应用与需要回答的临床问题相关的研究结果。在本文中，我们概述了一种以可通过研究回答的形式提出临床问题的方法，然后找到最相关的研究。接下来，我们定义了将研究结果应用于治疗决策的过程中的两个步骤，并讨论了对有效性的威胁。我们总结了统计结论有效性、内部有效性、结构有效性和外部有效性的概念。我们使用需要选择抗精神病药物的临床病例来说明该方法。我们讨论了精神分裂症的干预有效性临床试验（CATIE）的结果，并考虑了 CATIE 中不同形式有效性的威胁。
