Morris M, Lack L, Dawson D
School of Social Sciences, Flinders University of South Australia, Bedford Park.
Sleep. 1990 Feb;13(1):1-14. doi: 10.1093/sleep/13.1.1.
It was predicted from free running and ultradian cycle studies that sleep-onset insomniacs would have endogenous circadian rhythms that were phase delayed compared to good sleepers. Thirteen sleep-onset insomniacs and nine good sleepers were selected to differ only in their sleep-onset latencies as confirmed by polysomnography. their rectal temperatures were measured over a 26-h constant routine and analyzed with best-fit Fourier curves including 24-h fundamental and 12-h harmonic components. The temperature rhythm markers of the insomniacs' rhythms were approximately 2.5 h later than the respective phases of the good sleepers. The usual bedtimes of the insomniacs fell within the "wake maintenance zone" of their delayed temperature rhythm. The good sleepers had typical bedtimes several hours after their "wake maintenance zone" and closer to their body temperature minimum. It was suggested that manipulations to phase advance the insomniacs' rhythms would reduce their sleep-onset latencies. It was also predicted that early morning insomnia results from phase advanced circadian rhythms and that sleep maintenance insomnia results from an abnormal phase relationship between the 24-h temperature rhythm and 12-h sleep-alert rhythm.
从自由运行和超日周期研究预测，入睡失眠者的内源性昼夜节律与良好睡眠者相比会出现相位延迟。选择了13名入睡失眠者和9名良好睡眠者，经多导睡眠图证实，他们仅在入睡潜伏期方面存在差异。在26小时的恒定作息期间测量他们的直肠温度，并用包括24小时基本成分和12小时谐波成分的最佳拟合傅里叶曲线进行分析。失眠者节律的温度节律标记比良好睡眠者的相应相位晚约2.5小时。失眠者的通常就寝时间落在其延迟温度节律的“觉醒维持区”内。良好睡眠者的典型就寝时间在其“觉醒维持区”之后数小时，且更接近其体温最低点。有人提出，使失眠者节律相位提前的操作将减少他们的入睡潜伏期。还预测清晨失眠是由昼夜节律相位提前导致的，而睡眠维持性失眠是由24小时温度节律与12小时睡眠-警觉节律之间的异常相位关系导致的。
