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[肝泡型包虫病:诊断与治疗]

[Hepatic alveolar echinococcosis: diagnosis and treatment].

作者信息

Lointier P, Beytout J, Dechelotte P

机构信息

Service de chirurgie générale et digestive, Hôtel-Dieu, Clermont-Ferrand.

出版信息

Rev Prat. 1990 Jan 21;40(3):214-9.

PMID:2305186
Abstract

Alveolar echinococcosis is a parasitic disease which is relatively rare in humans. It almost exclusively affects patients of rural origin living in enzootic regions (Eastern France, Auvergne) and most lesions are in the liver. Several anatomico-clinical forms have been described; the most frequent is the multilocular form, but the disease may consist of one single cyst or abscess. The liver structure is always deeply altered, with compression, inflammation or superinfection. Jaundice, liver enlargement, abdominal pain or signs of secondary localizations are manifestations that lead to the discovery of hepatic alveolar echinococcosis. The anatomical features of the lesions are demonstrated by ultrasounds and computerized tomography. The main differential diagnosis is tumoral pathology of the liver. In most cases the diagnosis of echinococcosis is confirmed by serological tests, although needle or even surgical biopsy might be necessary. Diagnosed at an early stage, alveolar echinococcosis can be amenable to surgical treatment (hepatectomy), and liver transplantation may even be performed. Medical treatment with benzimidazoles seems to be promising.

摘要

肺泡型棘球蚴病是一种在人类中相对罕见的寄生虫病。它几乎只影响生活在动物疫区(法国东部、奥弗涅)的农村居民,且大多数病变位于肝脏。已经描述了几种解剖临床类型;最常见的是多房型,但该病可能由单个囊肿或脓肿组成。肝脏结构总是会发生深度改变,伴有压迫、炎症或重复感染。黄疸、肝脏肿大、腹痛或继发性局部症状是导致发现肝肺泡型棘球蚴病的表现。病变的解剖特征通过超声和计算机断层扫描显示。主要的鉴别诊断是肝脏肿瘤性病变。在大多数情况下,棘球蚴病的诊断通过血清学检测得以证实,不过可能需要进行穿刺活检甚至手术活检。如果在早期阶段确诊,肺泡型棘球蚴病可以接受手术治疗(肝切除术),甚至可能进行肝移植。使用苯并咪唑进行药物治疗似乎很有前景。

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