Döring A, Paul F, Dörr J
NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Charité Campus Mitte, Charitéplatz 1, 10117, Berlin, Deutschland.
Nervenarzt. 2013 Feb;84(2):173-89. doi: 10.1007/s00115-012-3645-z.
In addition to its important role in bone metabolism and calcium homeostasis an increasing number of beneficial effects are being attributed to vitamin D. Because of its suggested immunomodulatory capacity vitamin D deficiency or disturbance in the vitamin D metabolism might be a risk factor for the development of autoimmune diseases, such as multiple sclerosis; but supplementation with vitamin D might also be a therapeutic option. Substantial epidemiologic evidence indicates an association between vitamin D levels and risk of multiple sclerosis, suggesting vitamin D to be one of the long searched environmental factors for the development of this most common chronic inflammatory disease of the central nervous system. Less consistent are the available data for modification of the disease course in already established multiple sclerosis.This review highlights possible interactions between vitamin D and multiple sclerosis and focuses on its putative involvement in the pathogenesis and its possible role for treatment of multiple sclerosis. In particular the as yet insufficiently investigated therapeutic aspect is currently being addressed in several high quality clinical trials.
除了在骨代谢和钙稳态中发挥重要作用外，维生素D还具有越来越多的有益作用。由于其具有免疫调节能力，维生素D缺乏或维生素D代谢紊乱可能是自身免疫性疾病（如多发性硬化症）发生的危险因素；但补充维生素D也可能是一种治疗选择。大量流行病学证据表明维生素D水平与多发性硬化症风险之间存在关联，这表明维生素D是长期以来一直在寻找的、导致这种最常见的中枢神经系统慢性炎症性疾病发生的环境因素之一。关于已确诊的多发性硬化症患者疾病进程改变的现有数据不太一致。本综述重点介绍了维生素D与多发性硬化症之间可能的相互作用，并聚焦于其在发病机制中的假定作用以及对多发性硬化症治疗的可能作用。特别是目前正在多项高质量临床试验中探讨尚未得到充分研究的治疗方面。
