Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, PO Box 855, Perth, Western Australia 6872, Australia.
Nat Rev Immunol. 2011 Aug 19;11(9):584-96. doi: 10.1038/nri3045.
Humans obtain most of their vitamin D through the exposure of skin to sunlight. The immunoregulatory properties of vitamin D have been demonstrated in studies showing that vitamin D deficiency is associated with poor immune function and increased disease susceptibility. The benefits of moderate ultraviolet (UV) radiation exposure and the positive latitude gradients observed for some immune-mediated diseases may therefore reflect the activities of UV-induced vitamin D. Alternatively, other mediators that are induced by UV radiation may be more important for UV-mediated immunomodulation. Here, we compare and contrast the effects of UV radiation and vitamin D on immune function in immunopathological diseases, such as psoriasis, multiple sclerosis and asthma, and during infection.
人体通过皮肤暴露于阳光中来获得大部分维生素 D。研究表明，维生素 D 缺乏与免疫功能不良和疾病易感性增加有关，从而证明了维生素 D 的免疫调节特性。因此，适度的紫外线 (UV) 辐射暴露的益处以及某些免疫介导性疾病观察到的正纬度梯度可能反映了 UV 诱导的维生素 D 的活性。或者，由 UV 辐射诱导的其他介质可能对 UV 介导的免疫调节更为重要。在这里，我们比较和对比了 UV 辐射和维生素 D 对免疫病理疾病（如牛皮癣、多发性硬化症和哮喘）以及感染期间的免疫功能的影响。
