Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Mol Biol Rep. 2012 Dec;39(12):11031-9. doi: 10.1007/s11033-012-2006-0. Epub 2012 Oct 9.
The ATP-binding cassette transporter A1 (ABCA1) R219K gene polymorphism has been suggested to lower the risk of coronary artery disease (CAD). However, research results remain debatable. Meta-analysis involving 2,730 CAD patients and 2,658 controls was performed to investigate the relationship between ABCA1 R219K gene polymorphism and CAD in Chinese population. A total of 14 studies which were obtained from electronic databases were analyzed. The pooled odds ratios (ORs) and their corresponding 95 % confidence intervals (95 % CIs) were estimated by a random effect model. A significant association between ABCA1 R219K gene polymorphism and CAD was found in the Chinese population under the following genetic models: an allelic genetic model (OR 0.70, 95 % CI 0.62-0.78, P < 0.00001), a recessive genetic model (OR 0.51, 95 % CI 0.41-0.64, P < 0.00001), an additive genetic model (OR 0.816, 95 % CI 0780-0.855, P = 0), a dominant genetic model (OR 1.326, 95 % CI 1.232-1.427, P = 0), a homozygote genetic model (OR 0.640, 95 % CI 0.575-0.712, P = 0), and a heterozygote genetic model (OR 0.640, 95 % CI 0.575-0.712, P = 0). The K allele of the ABCA1 R219K gene has a protective role for CAD risk in Chinese population and is possibly associated with decreased CAD susceptibility.
载脂蛋白 A1（ABCA1）R219K 基因多态性被认为可以降低冠心病（CAD）的风险。然而，研究结果仍存在争议。进行了一项荟萃分析，纳入了 2730 名 CAD 患者和 2658 名对照，以研究中国人 ABCA1 R219K 基因多态性与 CAD 之间的关系。从电子数据库中获得了 14 项研究进行分析。采用随机效应模型估计合并的比值比（OR）及其相应的 95%置信区间（95%CI）。在中国人群中，ABCA1 R219K 基因多态性与 CAD 之间存在显著相关性，在以下遗传模型中：等位基因遗传模型（OR 0.70，95%CI 0.62-0.78，P<0.00001）、隐性遗传模型（OR 0.51，95%CI 0.41-0.64，P<0.00001）、加性遗传模型（OR 0.816，95%CI 0780-0.855，P=0）、显性遗传模型（OR 1.326，95%CI 1.232-1.427，P=0）、纯合遗传模型（OR 0.640，95%CI 0.575-0.712，P=0）和杂合遗传模型（OR 0.640，95%CI 0.575-0.712，P=0）。ABCA1 R219K 基因的 K 等位基因对中国人群 CAD 风险具有保护作用，可能与 CAD 易感性降低有关。
