Gene -509C/T Polymorphism and Coronary Artery Disease: An Updated Meta-Analysis Involving 11,701 Subjects.

The gene -509C/T polymorphism has been suggested to be associated with increased coronary artery disease (CAD) risk. However, the individual studies results are still inconsistent. To investigate the relationship between gene -509C/T polymorphism and CAD, a meta-analysis involving 11,701 participants from 8 individual studies was conducted. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals were evaluated by using random or fixed effect models. A significant association between gene -509C/T polymorphism and CAD was detected in the total population under allelic (OR: 1.130, 95% CI: 1.060-1.200, = 0.0001), recessive (OR: 1.390, 95% CI: 1.100-1.750, = 0.006), dominant (OR: 0.857, 95% CI: 0.785-0.935, = 2.507 × 10), homozygous (OR: 1.258, 95% CI: 1.098-1.442, = 0.001), heterozygous (OR: 1.147, 95% CI: 1.046-1.257, = 0.003), and additive genetic models (OR: 1.131, 95% CI: 1.063-1.204, = 5.442 × 10). In the subgroup analysis, there was a significant association between them in Chinese population under all of the genetic models ( < 0.05), except under the heterozygous genetic model ( > 0.05). In the Caucasian subgroup, a significant association between them was also detected under all of the genetic models ( < 0.05), except under the recessive genetic model ( > 0.05). gene -509C/T polymorphism was significantly associated with increased CAD risk. The people with T allele of gene -509C/T polymorphism might be predisposed to CAD.