Li Yan-Yan, Zhou Yan-Hong, Gong Ge, Geng Hong-Yu, Yang Xin-Xing
Department of geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
Front Physiol. 2017 Feb 23;8:108. doi: 10.3389/fphys.2017.00108. eCollection 2017.
The gene -509C/T polymorphism has been suggested to be associated with increased coronary artery disease (CAD) risk. However, the individual studies results are still inconsistent. To investigate the relationship between gene -509C/T polymorphism and CAD, a meta-analysis involving 11,701 participants from 8 individual studies was conducted. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals were evaluated by using random or fixed effect models. A significant association between gene -509C/T polymorphism and CAD was detected in the total population under allelic (OR: 1.130, 95% CI: 1.060-1.200, = 0.0001), recessive (OR: 1.390, 95% CI: 1.100-1.750, = 0.006), dominant (OR: 0.857, 95% CI: 0.785-0.935, = 2.507 × 10), homozygous (OR: 1.258, 95% CI: 1.098-1.442, = 0.001), heterozygous (OR: 1.147, 95% CI: 1.046-1.257, = 0.003), and additive genetic models (OR: 1.131, 95% CI: 1.063-1.204, = 5.442 × 10). In the subgroup analysis, there was a significant association between them in Chinese population under all of the genetic models ( < 0.05), except under the heterozygous genetic model ( > 0.05). In the Caucasian subgroup, a significant association between them was also detected under all of the genetic models ( < 0.05), except under the recessive genetic model ( > 0.05). gene -509C/T polymorphism was significantly associated with increased CAD risk. The people with T allele of gene -509C/T polymorphism might be predisposed to CAD.
基因-509C/T多态性被认为与冠状动脉疾病（CAD）风险增加有关。然而，个别研究结果仍不一致。为了研究基因-509C/T多态性与CAD之间的关系，我们对来自8项个体研究的11701名参与者进行了荟萃分析。采用随机或固定效应模型评估合并比值比（OR）及其相应的95%置信区间。在等位基因（OR：1.130，95%CI：1.060 - 1.200，P = 0.0001）、隐性（OR：1.390，95%CI：1.100 - 1.750，P = 0.006）、显性（OR：0.857，95%CI：0.785 - 0.935，P = 2.507×10）、纯合子（OR：1.258，95%CI：1.098 - 1.442，P = 0.001）、杂合子（OR：1.147，95%CI：1.046 - 1.257，P = 0.003）以及加性遗传模型（OR：1.131，95%CI：1.063 - 1.204，P = 5.442×10）下的总人群中，检测到基因-509C/T多态性与CAD之间存在显著关联。在亚组分析中，除杂合子遗传模型外（P＞0.05），在中国人群的所有遗传模型下（P＜0.05）均检测到它们之间存在显著关联。在白种人亚组中，除隐性遗传模型外（P＞0.05），在所有遗传模型下也检测到它们之间存在显著关联（P＜0.05）。基因-509C/T多态性与CAD风险增加显著相关。具有基因-509C/T多态性T等位基因的人可能易患CAD。
