Department of Neurology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Sleep Breath. 2013 May;17(2):803-10. doi: 10.1007/s11325-012-0767-2. Epub 2012 Sep 29.
The Berlin Questionnaire (BQ) is a useful tool to identify the high-risk group for obstructive sleep apnea (OSA) in the primary care sites or hospital, but the usefulness of the BQ to identify the high-risk group for OSA in the general population has not been evaluated. The purpose of our study was to develop the Korean version of the BQ (KBQ) and evaluate the usefulness of the BQ in identifying patients with OSA in the general population.
A total of 1,305 subjects were included in a population-based door-to-door cross-sectional study. For validation of the KBQ, an overnight polysomnography (PSG) was performed on 101 subjects who were randomly selected considering their age, sex, and risk group classification at a controlled sleep laboratory.
The KBQ showed a relatively good to excellent internal consistency (Cronbach's α correlation 0.64-0.78) and test-retest reliability (intraclass correlation 0.92). The apnea-hypopnea index (AHI) was significantly correlated with the scores in each category and the total scores of the KBQ. In addition, high risk grouping based on the KBQ predicted an AHI ≥ 5 with a sensitivity of 0.69 and a specificity of 0.83. According to the risk categorization based on the KBQ, 26.1 % subjects were in the high-risk group for OSA which was similar to the prevalence of OSA in a previous large epidemiological study using PSG in Korea.
This is the first study to confirm the usefulness of the BQ as a screening tool for OSA by prioritizing subjects at high risk for OSA in the general population.
柏林问卷（BQ）是一种在初级保健场所或医院识别阻塞性睡眠呼吸暂停（OSA）高危人群的有用工具，但BQ 用于识别普通人群中 OSA 高危人群的有用性尚未得到评估。我们的研究目的是开发 BQ 的韩文版本（KBQ），并评估 BQ 在识别普通人群中 OSA 患者方面的有用性。
一项基于人群的逐户横断面研究共纳入 1305 例受试者。为了验证 KBQ，我们对 101 例随机选择的受试者在受控睡眠实验室进行了整夜多导睡眠图（PSG）检查，考虑到他们的年龄、性别和风险组分类。
KBQ 表现出相对较好到优秀的内部一致性（Cronbach's α 相关系数为 0.64-0.78）和重测信度（组内相关系数为 0.92）。呼吸暂停低通气指数（AHI）与每个类别和 KBQ 的总分的得分显著相关。此外，基于 KBQ 的高风险分组预测 AHI≥5 的灵敏度为 0.69，特异性为 0.83。根据 KBQ 的风险分类，26.1%的受试者为 OSA 的高危人群，这与韩国之前使用 PSG 的大型流行病学研究中 OSA 的患病率相似。
这是第一项通过优先考虑普通人群中 OSA 高危人群来确认 BQ 作为 OSA 筛查工具有用性的研究。
