细胞骨架对心脏-肾脏系统中 TRPC 通道的调节。
Cytoskeletal regulation of TRPC channels in the cardiorenal system.
机构信息
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Curr Hypertens Rep. 2012 Dec;14(6):492-7. doi: 10.1007/s11906-012-0313-4.
Abstract
Transient receptor potential canonical (TRPC) channels have been implicated in several aspects of cardiorenal physiology including regulation of blood pressure, vasoreactivity, vascular remodeling, and glomerular filtration. Gain and loss of function studies also support the role of TRPC channels in adverse remodeling associated with cardiac hypertrophy and heart failure. This review discusses TRP channels in the cardiovascular and glomerular filtration systems and their role in disease pathogenesis. We describe the regulation of gating of TRPC channels in the cardiorenal system as well as the influence on activation of these channels by the underlying cytoskeleton and scaffolding proteins. We then focus on the role of TRP channels in the pathogenesis of adverse cardiac remodeling and as potential therapeutic targets in the treatment of heart failure.
摘要
瞬时受体电位经典型 (TRPC) 通道参与了心脏肾生理学的多个方面，包括血压调节、血管反应性、血管重塑和肾小球滤过。功能获得和功能丧失研究也支持 TRPC 通道在与心脏肥大和心力衰竭相关的不良重塑中的作用。本综述讨论了心血管和肾小球滤过系统中的 TRP 通道及其在疾病发病机制中的作用。我们描述了心脏肾系统中 TRPC 通道的门控调节，以及基底细胞骨架和支架蛋白对这些通道激活的影响。然后，我们专注于 TRP 通道在不良心脏重塑发病机制中的作用以及在心力衰竭治疗中作为潜在治疗靶点的作用。
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