Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Stat Med. 2012 Nov 10;31(25):3051-3. doi: 10.1002/sim.5400.
Comparative effectiveness research represents the kind of research that arguably more directly affects clinical practice and policy. It includes observational studies, clinical trials, and systematic syntheses of existing literature. In this commentary, I argue for the ongoing and critical role of randomization in comparative effectiveness, noting the key differences between practical and explanatory trials.
比较效果研究代表了一种更直接影响临床实践和政策的研究。它包括观察性研究、临床试验和现有文献的系统综合。在这篇评论中，我主张随机化在比较效果研究中的持续和关键作用，并指出实用试验和解释性试验之间的关键区别。
