Division of Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL 33163, USA.
J Natl Compr Canc Netw. 2012 Oct 1;10 Suppl 2:S65-8. doi: 10.6004/jnccn.2012.0179.
Surgery, radiotherapy, and chemotherapy remain standard treatment options for patients with head and neck carcinomas, but because they are often associated with complications, there is room for improvement. Although not widely practiced and still off-label, photodynamic therapy (PDT) is a promising alternative for superficial malignant or premalignant lesions of the upper aerodigestive tract. It also may be useful for those with recurrent surface disease after surgery or radiotherapy. After an historic look at the data on PDT for head and neck tumors, this article offers a current perspective from a fairly selective PDT program that has achieved dramatic lasting responses. Where PDT may fit in the treatment spectrum for head and neck cancers is one of the unanswered questions requiring further study.
手术、放疗和化疗仍然是头颈部癌患者的标准治疗选择，但由于它们常伴有并发症，因此仍有改进的空间。光动力疗法（PDT）虽然应用不广泛，且仍属于超适应证用药，但作为上呼吸道表面恶性或癌前病变的一种有前途的替代治疗方法，具有一定的应用前景。对于手术后或放疗后表面疾病复发的患者，PDT 也可能有用。在对头颈部肿瘤 PDT 数据进行历史性回顾之后，本文从一个相当有选择性的 PDT 项目的角度提供了当前的观点，该项目取得了显著的持久反应。PDT 在头颈部癌症治疗谱中的位置是需要进一步研究的未解决问题之一。
