College of Pharmacy, Taishan Medical University, Taian, Shandong, PR, China.
Phytother Res. 2013 Aug;27(8):1225-31. doi: 10.1002/ptr.4856. Epub 2012 Oct 10.
Yerba Mate tea (Mate) is believed to be a natural source of cardioprotective lipid-lowering and antioxidant compounds. In this study, the antihyperlipidemic and antioxidant effects of Mate tea in a rat hyperlipidemia model were investigated. Male Sprague-Dawley rats were divided randomly into five groups and fed varying diets: standard diet, hyperlipidemic diet, and hyperlipidemic diet supplemented with low, moderate, or high concentrations of Mate tea aqueous extract (1%, 2%, and 4% w/v, respectively). Compared to the hyperlipidemic control group, Mate tea reduced significantly the total body weight and lowered serum levels of total cholesterol, triglyceride, and low-density lipoprotein-cholesterol, and caused the elevation of serum levels of high-density lipoprotein-cholesterol. Moreover, activities of superoxide dismutase and glutathione peroxidase in serum were elevated significantly, whereas the levels of malondialdehyde decreased. In addition, Mate tea treatment ameliorated significantly the severe fatty degeneration of liver cells that occurred in the hyperlipidemic groups. The relative levels of sterol regulatory element binding protein 1 and its target fatty acid synthase, as well as acetyl-CoA carboxylase mRNA transcripts were reduced, whereas peroxisome proliferator-activated receptor alpha mRNA transcripts were elevated in the Mate tea groups. Our results suggest that Mate tea exerts strong antioxidant and lipid-lowering effects, prevents hepatic fatty deposition, and regulates the expression of lipid metabolic regulators. It can therefore be used to reduce the risk of atherosclerosis.
马黛茶（Mate）被认为是一种天然的具有心脏保护作用的降脂和抗氧化化合物来源。在这项研究中，研究了马黛茶在大鼠高血脂模型中的降脂和抗氧化作用。雄性 Sprague-Dawley 大鼠随机分为五组，分别给予不同的饮食：标准饮食、高脂饮食和高脂饮食分别补充低、中、高浓度的马黛茶水提物（分别为 1%、2%和 4%w/v）。与高脂对照组相比，马黛茶显著降低了总体重，降低了血清总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平，并升高了血清高密度脂蛋白胆固醇水平。此外，血清中超氧化物歧化酶和谷胱甘肽过氧化物酶的活性显著升高，而丙二醛的水平降低。此外，马黛茶治疗显著改善了高脂血症组严重的肝细胞脂肪变性。马黛茶组固醇调节元件结合蛋白 1 及其靶脂肪酸合酶和乙酰辅酶 A 羧化酶 mRNA 转录物的相对水平降低，而过氧化物酶体增殖物激活受体α mRNA 转录物升高。我们的结果表明，马黛茶具有很强的抗氧化和降脂作用，可防止肝脏脂肪沉积，并调节脂质代谢调节剂的表达。因此，它可用于降低动脉粥样硬化的风险。
