Chadha Vandana Srikrishna, Bhat Khandige Mahalinga
Department of Periodontics, Manav Rachna Dental College, Faridabad, Haryana, India.
J Indian Soc Periodontol. 2012 Apr;16(2):200-6. doi: 10.4103/0972-124X.99262.
Investigators have sought different methods to deliver antimicrobials to periodontal pockets. This study was designed to assess the efficacy of locally made doxycycline gel versus locally made doxycycline implant as biodegradable controlled local delivery systems, by evaluating the pharmacological drug release and improvement in gingival status, gain in attachment, and reduction in pocket depth.
Thirty patients with localized periodontal pockets ≥5 mm were randomly divided into three groups. The first group received the doxycycline gel, the second the doxycycline implant, and the third received only scaling and root planing (the control group). The patients in the first two groups were selected for the drug release. Clinical parameters such as gingival index, plaque index, probing depth, and attachment levels were recorded at baseline and the 90(th) day. Gingival crevicular fluid (GCF) and saliva samples were collected 1 hour following gel and implant placement and then on the 10(th), 30(th), and 60(th) days.
There was a statistically significant difference in the release of doxycycline from the gel when compared with the implant in the GCF and saliva on the 10(th) and 30(th) days. All the three groups showed improvement in clinical parameters. The improvements in both gel and implant groups were greater when compared with the control group with no statistically significant difference between the implant and gel systems.
The use of local delivery of doxycycline through gel and Implant media further enhances the positive changes obtained following scaling and root planing. The release of doxycycline from the implant and the gel was comparable.
研究人员一直在寻找将抗菌药物输送到牙周袋的不同方法。本研究旨在通过评估药物释放情况以及牙龈状况的改善、附着增加和牙周袋深度减少，来评估自制强力霉素凝胶与自制强力霉素植入物作为可生物降解的局部控释系统的疗效。
30例患有≥5mm局限性牙周袋的患者被随机分为三组。第一组接受强力霉素凝胶，第二组接受强力霉素植入物，第三组仅接受龈下刮治和根面平整（对照组）。前两组患者被选取用于药物释放研究。在基线和第90天时记录临床参数，如牙龈指数、菌斑指数、探诊深度和附着水平。在放置凝胶和植入物后1小时，然后在第10、30和60天时收集龈沟液（GCF）和唾液样本。
在第10天和第30天时，与植入物相比，凝胶中强力霉素在GCF和唾液中的释放存在统计学显著差异。所有三组的临床参数均有改善。与对照组相比，凝胶组和植入物组的改善更大，植入物组和凝胶组之间无统计学显著差异。
通过凝胶和植入物介质局部递送强力霉素进一步增强了龈下刮治和根面平整后获得的积极变化。植入物和凝胶中强力霉素的释放相当。
