Mistry Surajit, Kundu Debabrata, Datta Someswar, Basu Debabrata
Department of Periodontics, Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India.
J Indian Soc Periodontol. 2012 Apr;16(2):241-6. doi: 10.4103/0972-124X.99269.
Several synthetic alloplastic materials have been used in the past as an implant in infrabony defects with a goal to reconstruct the lost part of attachment apparatus via new osseous tissue formation. The present study was undertaken to evaluate and compare clinico-radiographically, the effect of bioactive glass (BG), hydroxyapatite (HA), and BG-HA composite bone graft particles in the treatment of human infra-bony periodontal defects.
Indigenous synthetic HA, BG, and BG-HA composite bone graft materials were developed in the laboratory. Twenty eight infrabony periodontal defects were equally distributed (i.e., seven defects) into four groups. The defects were treated separately with three types of graft materials and non-grafted manner (open flap debridement alone, control) to evaluate both the soft and hard tissue responses after six months of surgery. Evaluation was done by studying different parameters such as plaque index, gingival index, relative attachment level, probing pocket depth, and radiographic bone fill in Intra Oral Peri-Apical radiograph.
The healing of defects was uneventful and free of any biological complications. The gain in relative attachment level, reduction of probing pocket depth, and bone fill was statistically significant in all four groups. BG and BG-HA synthetic bone graft implanted sites showed significant bone fill (P<0.05) than hydroxyapatite and unimplanted control sites.
The performance of BG and its composite was better compared to HA and open flap debridement alone for the reconstruction of infrabony defects. The BG-HA composite particles may effectively be used as an alternative bone graft material for infrabony defects.
过去曾使用多种合成异体材料作为骨下袋缺损的植入物，目的是通过新骨组织形成来重建附着装置的缺失部分。本研究旨在通过临床影像学评估和比较生物活性玻璃（BG）、羟基磷灰石（HA）和BG-HA复合骨移植颗粒治疗人类骨下袋牙周缺损的效果。
在实验室研发了国产合成HA、BG和BG-HA复合骨移植材料。28例骨下袋牙周缺损被平均分为四组（即每组7个缺损）。分别用三种移植材料和非移植方式（仅翻开瓣清创，作为对照）治疗缺损，以评估术后6个月的软硬组织反应。通过研究不同参数进行评估，如菌斑指数、牙龈指数、相对附着水平、探诊袋深度以及口腔根尖片上的影像学骨填充情况。
缺损愈合顺利，无任何生物学并发症。所有四组的相对附着水平增加、探诊袋深度减小和骨填充在统计学上均有显著意义。植入BG和BG-HA合成骨移植材料的部位显示出比羟基磷灰石和未植入的对照部位更显著的骨填充（P<0.05）。
与HA和仅翻开瓣清创相比，BG及其复合材料在重建骨下袋缺损方面表现更好。BG-HA复合颗粒可有效用作骨下袋缺损的替代骨移植材料。
