牙周再生中的生物活性玻璃：现有策略与未来展望——文献综述

Cannillo Valeria, Salvatori Roberta, Bergamini Stefania, Bellucci Devis, Bertoldi Carlo

Department of Engineering "Enzo Ferrari", University of Modena and Reggio Emilia, Via P. Vivarelli 10, 41125 Modena, Italy.

Department of Industrial Engineering and BIOtech Research Center, University of Trento, 38123 Trento, Italy.

Materials (Basel). 2022 Mar 16;15(6):2194. doi: 10.3390/ma15062194.

The present review deals with bioactive glasses (BGs), a class of biomaterials renowned for their osteoinductive and osteoconductive capabilities, and thus widely used in tissue engineering, i.e., for the repair and replacement of damaged or missing bone. In particular, the paper deals with applications in periodontal regeneration, with a special focus on in vitro, in vivo and clinical studies. The study reviewed eligible publications, identified on the basis of inclusion/exclusion criteria, over a ranged time of fifteen years (from 1 January 2006 to 31 March 2021). While there are many papers dealing with in vitro tests, only a few have reported in vivo (in animal) research, or even clinical trials. Regardless, BGs seem to be an adequate choice as grafts in periodontal regeneration.

本综述涉及生物活性玻璃（BGs），这是一类以其骨诱导和骨传导能力而闻名的生物材料，因此广泛应用于组织工程，即用于修复和替换受损或缺失的骨骼。特别是，本文探讨了生物活性玻璃在牙周组织再生中的应用，并特别关注体外、体内和临床研究。该研究回顾了根据纳入/排除标准确定的在十五年时间范围内（从2006年1月1日至2021年3月31日）的合格出版物。虽然有许多关于体外测试的论文，但只有少数报道了体内（在动物身上）研究或甚至临床试验。无论如何，生物活性玻璃似乎是牙周组织再生中作为移植物的合适选择。