传统中医药治疗痴呆行为和精神症状的新可能。
New possibility of traditional Chinese and Japanese medicine as treatment for behavioral and psychiatric symptoms in dementia.
机构信息
Yuli Hospital, DOH, Hualien, Taiwan.
出版信息
Clin Interv Aging. 2012;7:393-6. doi: 10.2147/CIA.S36509. Epub 2012 Oct 4.
Abstract
Yokukansan, one of the Kampo prescriptions, is composed of seven herbaceous plants and was developed in China in the 16th century as a cure for restlessness and agitation in children. Yokukansan has also become a popular drug combination in Japan, especially for the behavioral and psychiatric symptoms of dementia (BPSD). Recent studies have shown that yokukansan might also be quite effective against BPSD occurring in association with other types of dementia, such as Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, frontotemporal dementia, and vascular dementia. Researchers have intensively investigated yokukansan, focusing on the pharmacological mechanisms against glutamate-mediated excitotoxicity. This traditional Chinese and Japanese medicine holds potential promise for improving BPSD in elderly patients suffering from dementia.
摘要
和汉三才汤，一种汉方处方，由七种草本植物组成，于 16 世纪在中国开发，用于治疗儿童的不安和烦躁。和汉三才汤在日本也成为一种流行的药物组合，特别是用于痴呆的行为和精神症状（BPSD）。最近的研究表明，和汉三才汤对于与其他类型痴呆（如阿尔茨海默病、路易体病、痴呆伴帕金森病、额颞叶痴呆和血管性痴呆）相关的 BPSD 也可能非常有效。研究人员对和汉三才汤进行了深入研究，重点研究了对抗谷氨酸介导的兴奋性毒性的药理机制。这种中药和日本药有希望改善患有痴呆的老年患者的 BPSD。
相似文献
1
New possibility of traditional Chinese and Japanese medicine as treatment for behavioral and psychiatric symptoms in dementia.
Clin Interv Aging. 2012;7:393-6. doi: 10.2147/CIA.S36509. Epub 2012 Oct 4.
2
A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia.
Int J Neuropsychopharmacol. 2009 Mar;12(2):191-9. doi: 10.1017/S146114570800970X. Epub 2008 Dec 11.
3
Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: an open-label trial.
Phytomedicine. 2012 Apr 15;19(6):524-8. doi: 10.1016/j.phymed.2012.02.008. Epub 2012 Mar 13.
4
Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease.
Geriatr Gerontol Int. 2017 Feb;17(2):211-218. doi: 10.1111/ggi.12696. Epub 2015 Dec 29.
5
Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):284-7. doi: 10.1016/j.pnpbp.2009.11.019. Epub 2009 Dec 3.
6
Efficacy and tolerability of risperidone, yokukansan, and fluvoxamine for the treatment of behavioral and psychological symptoms of dementia: a blinded, randomized trial.
J Clin Psychopharmacol. 2013 Oct;33(5):600-7. doi: 10.1097/JCP.0b013e31829798d5.
7
Yokukansan in the Treatment of Behavioral and Psychological Symptoms of Dementia: An Updated Meta-Analysis of Randomized Controlled Trials.
J Alzheimers Dis. 2016 Sep 6;54(2):635-43. doi: 10.3233/JAD-160418.
8
Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress.
J Ethnopharmacol. 2012 Sep 28;143(2):533-9. doi: 10.1016/j.jep.2012.07.007. Epub 2012 Jul 20.
9
Improvement in delusions and hallucinations in patients with dementia with Lewy bodies upon administration of yokukansan, a traditional Japanese medicine.
Psychogeriatrics. 2012 Dec;12(4):235-41. doi: 10.1111/j.1479-8301.2012.00413.x.
10
Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer's disease.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Apr 16;34(3):532-6. doi: 10.1016/j.pnpbp.2010.02.013. Epub 2010 Feb 17.
引用本文的文献
1
Apathy in Dementia: Systematic Review of Recent Evidence on Pharmacological Treatments.
Curr Psychiatry Rep. 2016 Nov;18(11):103. doi: 10.1007/s11920-016-0737-7.
2
Influences of yokukansankachimpihange on aggressive behavior of zinc-deficient mice and actions of the ingredients on excessive neural exocytosis in the hippocampus of zinc-deficient rats.
Exp Anim. 2016 Nov 1;65(4):353-361. doi: 10.1538/expanim.16-0028. Epub 2016 May 30.
3
Outcomes of Inpatient Treatment for Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease Versus Dementia With Lewy Bodies.
Prim Care Companion CNS Disord. 2015 Oct 1;17(5). doi: 10.4088/PCC.15m01785. eCollection 2015.
4
Effect of modified Bo-yang-Hwan-o-Tang, a polyherbal medicine on the hippocampal neuronal damage in a rat model of global ischemia.
Pharmacogn Mag. 2015 Jul-Sep;11(43):665-73. doi: 10.4103/0973-1296.160445.
5
Yokukansan and its ingredients as possible treatment options for schizophrenia.
Neuropsychiatr Dis Treat. 2014 Sep 1;10:1629-34. doi: 10.2147/NDT.S67607. eCollection 2014.
6
The effect of the kampo medicine yokukansan on preoperative anxiety and sedation levels.
Evid Based Complement Alternat Med. 2014;2014:965045. doi: 10.1155/2014/965045. Epub 2014 Mar 31.
7
Antianxiety-like effects of Chimpi (dried citrus peels) in the elevated open-platform test.
Molecules. 2013 Aug 20;18(8):10014-23. doi: 10.3390/molecules180810014.
本文引用的文献
1
Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: an open-label trial.
Phytomedicine. 2012 Apr 15;19(6):524-8. doi: 10.1016/j.phymed.2012.02.008. Epub 2012 Mar 13.
2
Integration of drugs and non-pharmacological intervention to Alzheimer patients.
Psychogeriatrics. 2012 Mar;12(1):1-2. doi: 10.1111/j.1479-8301.2012.00410.x.
3
Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review.
Phytother Res. 2010 Sep;24(9):1265-70. doi: 10.1002/ptr.3146.
4
Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer's disease.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Apr 16;34(3):532-6. doi: 10.1016/j.pnpbp.2010.02.013. Epub 2010 Feb 17.
5
Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):284-7. doi: 10.1016/j.pnpbp.2009.11.019. Epub 2009 Dec 3.
6
Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells.
Neuroscience. 2009 Apr 10;159(4):1397-407. doi: 10.1016/j.neuroscience.2009.02.004. Epub 2009 Feb 7.
7
Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease.
J Ethnopharmacol. 2009 Feb 25;122(1):157-62. doi: 10.1016/j.jep.2008.12.010. Epub 2008 Dec 25.
8
Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Mar 17;33(2):308-11. doi: 10.1016/j.pnpbp.2008.12.008. Epub 2008 Dec 24.
9
A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia.
Int J Neuropsychopharmacol. 2009 Mar;12(2):191-9. doi: 10.1017/S146114570800970X. Epub 2008 Dec 11.
10
Dementia in Taiwan: past, present, and future.
Acta Neurol Taiwan. 2008 Sep;17(3):153-61.
Zotero 插件