传统中医药治疗痴呆行为和精神症状的新可能。
New possibility of traditional Chinese and Japanese medicine as treatment for behavioral and psychiatric symptoms in dementia.
机构信息
Yuli Hospital, DOH, Hualien, Taiwan.
出版信息
Clin Interv Aging. 2012;7:393-6. doi: 10.2147/CIA.S36509. Epub 2012 Oct 4.
Abstract
Yokukansan, one of the Kampo prescriptions, is composed of seven herbaceous plants and was developed in China in the 16th century as a cure for restlessness and agitation in children. Yokukansan has also become a popular drug combination in Japan, especially for the behavioral and psychiatric symptoms of dementia (BPSD). Recent studies have shown that yokukansan might also be quite effective against BPSD occurring in association with other types of dementia, such as Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, frontotemporal dementia, and vascular dementia. Researchers have intensively investigated yokukansan, focusing on the pharmacological mechanisms against glutamate-mediated excitotoxicity. This traditional Chinese and Japanese medicine holds potential promise for improving BPSD in elderly patients suffering from dementia.
摘要
和汉三才汤，一种汉方处方，由七种草本植物组成，于 16 世纪在中国开发，用于治疗儿童的不安和烦躁。和汉三才汤在日本也成为一种流行的药物组合，特别是用于痴呆的行为和精神症状（BPSD）。最近的研究表明，和汉三才汤对于与其他类型痴呆（如阿尔茨海默病、路易体病、痴呆伴帕金森病、额颞叶痴呆和血管性痴呆）相关的 BPSD 也可能非常有效。研究人员对和汉三才汤进行了深入研究，重点研究了对抗谷氨酸介导的兴奋性毒性的药理机制。这种中药和日本药有希望改善患有痴呆的老年患者的 BPSD。
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