Department of Pediatrics, Show Chwan Memorial Hospital, Changhua, Taiwan.
J Microbiol Immunol Infect. 2013 Aug;46(4):295-301. doi: 10.1016/j.jmii.2012.07.002. Epub 2012 Oct 9.
BACKGROUND/PURPOSE: Environmental factors, different ages, and detection methods might affect the profiles of allergy sensitization and confound the diagnosis of allergic diseases. The purpose of this study was to investigate the different profiles of allergen sensitization in different ages, geographic areas, and detection methods.
We analyzed the patients who received allergen sensitization tests by the automated microfluidic-based immunoassay system (BioIC) method at Show Chwan Memorial Hospital in Changhua City and at Chang Bing Show Chwan Hospital in Lu-gang from January 2011 to December 2011. Results were compared in different ages (3-6, 7-18, and ≥19), different geographic areas, and different detection methods and analyzed by Chi-square or Fisher exact test depending on sample size.
A total of 1145 patients were analyzed. The younger the age, the higher the food allergy sensitization rate is found (26.6% vs. 14.7% vs.11.1% p < 0.001). The older the age, the higher the sensitization of Blomia tropicalis occurs (33.4% vs.15.1% p < 0.001). The food allergen specific IgE directed against egg white was higher in coast area than city (15.4% vs. 3%, p = 0.015). A higher rate of pollen sensitization was found in the detection by BioIC method (Bermuda grass, 17.2%; Timothy, 12.3%; ragweed, 5.7%). The sensitization rates of cockroach and cat dander were lower in both city and coast areas.
Children have higher food allergy sensitization and adults have higher Blomia tropicalis sensitization. Children living in Changhua area no matter in city or coast area had a higher pollen sensitization rate but lower cat or dog dander sensitization rate. Apparently, age, environmental factors, and different methods significantly affect the allergen sensitization in the different areas of Taiwan.
背景/目的：环境因素、不同年龄和检测方法可能会影响过敏致敏的特征，并混淆过敏性疾病的诊断。本研究的目的是探讨不同年龄、地理区域和检测方法下过敏原致敏的不同特征。
我们分析了 2011 年 1 月至 12 月在彰化基督教医院和鹿港基督教医院接受基于自动化微流控免疫分析系统（BioIC）方法进行过敏原致敏检测的患者。根据年龄（3-6 岁、7-18 岁和≥19 岁）、地理区域和检测方法对结果进行比较，并根据样本量采用卡方检验或 Fisher 确切概率法进行分析。
共分析了 1145 例患者。年龄越小，食物过敏致敏率越高（26.6%比 14.7%比 11.1%，p<0.001）。年龄越大，对 Bermuda 草（17.2%）、Timothy 草（12.3%）和豚草（5.7%）的花粉致敏率越高。在城市地区，蛋清特异性 IgE 过敏原检测阳性率高于海岸地区（15.4%比 3%，p=0.015）。
儿童食物过敏致敏率较高，成人 Blomia tropicalis 致敏率较高。居住在彰化地区的儿童，无论在城市还是海岸地区，花粉致敏率较高，但猫或狗皮屑致敏率较低。显然，年龄、环境因素和不同的方法显著影响台湾不同地区的过敏原致敏情况。
