State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China.
Planta Med. 2012 Nov;78(17):1867-72. doi: 10.1055/s-0032-1315392. Epub 2012 Oct 11.
Five unusual lactonic enamino ketones, gentiocrucines A-E (1-5), were isolated from Swertia macrosperma and S. angustifolia. Their structures were determined based on extensive spectroscopic analyses (IR, UV, MS, 1D- and 2D-NMR). By anti-HBV assay on the HepG 2.2.15 cell line in vitro, compound 1 inhibited both the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 3.14 and 3.35 mM, and compound 5 only inhibited the secretion of HBsAg with an IC50 value of 2.07 mM.
从川西獐牙菜和狭叶獐牙菜中分离得到了 5 个非典型的内酯亚氨基酮类化合物，分别命名为 gentio 苦酮 A-E（1-5）。基于广泛的光谱分析（IR、UV、MS、1D 和 2D-NMR）确定了它们的结构。通过体外 HepG 2.2.15 细胞系抗 HBV 试验，化合物 1 对乙型肝炎病毒表面抗原（HBsAg）和乙型肝炎病毒 e 抗原（HBeAg）的分泌均有抑制作用，IC50 值分别为 3.14 和 3.35 mM，化合物 5 仅对 HBsAg 的分泌有抑制作用，IC50 值为 2.07 mM。
