Departamento de Química Orgánica, Centro Singular de Investigación en Química Biológica y Materiales Moleculares y Unidad Asociada al CSIC, Campus Vida, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Org Biomol Chem. 2012 Nov 28;10(44):8762-6. doi: 10.1039/c2ob26612a.
In this study, a novel dimer-forming cyclic peptide composed exclusively by cyclic γ-amino acids with a saccharide-like outer surface is described. The antiparallel β-sheet type hydrogen bonding interactions responsible for the large association constant in non-polar solvents constitute a suitable model for a novel class of self-assembling peptide nanotubes.
在这项研究中，描述了一种新型的二聚体形成的环状肽，它完全由环状 γ-氨基酸组成，具有类似糖的外表面。负责在非极性溶剂中形成大的结合常数的反平行 β-折叠氢键相互作用构成了一类新型的自组装肽纳米管的合适模型。
