Department of Obstetrics & Gynaecology, National University Hospital, Singapore.
Curr Drug Targets. 2012 Dec;13(13):1649-53. doi: 10.2174/138945012803530044.
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Discovery of novel therapeutic opportunities for EOC is important for the improvement of clinical outcome of the patients. Emerging evidence is suggesting that epithelial-mesenchymal transition (EMT) plays a crucial role in the aggressiveness in EOC including increasing migration and invasion ability, contributing to chemoresistance and cancer stem cell populations. Targeting EMT in EOC thus offers an attractive therapeutic option.
上皮性卵巢癌（EOC）是最致命的妇科恶性肿瘤。为改善患者的临床结局，发现 EOC 的新治疗机会非常重要。新出现的证据表明，上皮-间充质转化（EMT）在上皮性卵巢癌的侵袭和迁移能力增强、化疗耐药和肿瘤干细胞群体形成等方面发挥着关键作用。因此，针对 EOC 的 EMT 提供了一种有吸引力的治疗选择。
