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半乳糖凝集素在上皮-间充质转化中的作用及其在组织修复、纤维化和癌症转移中的机制。

Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis.

机构信息

Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile.

Centro Científico y Tecnológico de Excelencia (CCTE) Ciencia y Vida, Santiago, Chile.

出版信息

Biol Res. 2024 Apr 4;57(1):14. doi: 10.1186/s40659-024-00490-5.

DOI:10.1186/s40659-024-00490-5
PMID:38570874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10993482/
Abstract

Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subcellular localization of different galectins vary among tissues and cell types and change during processes of tissue repair, fibrosis and cancer where epithelial cells loss differentiation while acquiring migratory mesenchymal phenotypes. The epithelial-mesenchymal transition (EMT) that occurs in the context of these processes can include modifications of glycosylation patterns of glycolipids and glycoproteins affecting their interactions with galectins. Moreover, overexpression of certain galectins has been involved in the development and different outcomes of EMT. This review focuses on the roles and mechanisms of Galectin-1 (Gal-1), Gal-3, Gal-4, Gal-7 and Gal-8, which have been involved in physiologic and pathogenic EMT contexts.

摘要

半乳糖凝集素是可溶性糖结合蛋白，可与广泛的糖蛋白和糖脂相互作用，并调节广泛的生理和病理过程。不同半乳糖凝集素的表达和亚细胞定位在组织和细胞类型之间有所不同，并在组织修复、纤维化和癌症等过程中发生变化，在此过程中上皮细胞失去分化，同时获得迁移的间充质表型。在这些过程中发生的上皮-间充质转化（EMT）可包括糖脂和糖蛋白糖基化模式的改变，影响它们与半乳糖凝集素的相互作用。此外，某些半乳糖凝集素的过表达与 EMT 的发生和不同结果有关。这篇综述重点介绍了 Galectin-1 (Gal-1)、Gal-3、Gal-4、Gal-7 和 Gal-8 在生理和病理 EMT 背景下的作用和机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/46c16a48fae4/40659_2024_490_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/1d506dc29765/40659_2024_490_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/a04fadd92053/40659_2024_490_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/d466ca1dd990/40659_2024_490_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/5a34b168496e/40659_2024_490_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/3ace8f1dfc56/40659_2024_490_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/46c16a48fae4/40659_2024_490_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/1d506dc29765/40659_2024_490_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/a04fadd92053/40659_2024_490_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/d466ca1dd990/40659_2024_490_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/5a34b168496e/40659_2024_490_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/3ace8f1dfc56/40659_2024_490_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83a4/10993482/46c16a48fae4/40659_2024_490_Fig6_HTML.jpg

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Tumour Biol. 2023;45(1):31-54. doi: 10.3233/TUB-230002.
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Unconventional protein secretion by gasdermin pores.
内源性半乳糖凝集素-8可预防急性肾损伤后的Th17细胞浸润和纤维化。
Mol Med. 2025 May 16;31(1):192. doi: 10.1186/s10020-025-01245-y.
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Galectin-8 drives ERK-dependent mitochondrial fragmentation, perinuclear relocation and mitophagy, with metabolic adaptations for cell proliferation.半乳糖凝集素-8驱动依赖细胞外调节蛋白激酶（ERK）的线粒体碎片化、核周重新定位和线粒体自噬，并伴有细胞增殖的代谢适应性变化。
Eur J Cell Biol. 2025 Jun;104(2):151488. doi: 10.1016/j.ejcb.2025.151488. Epub 2025 Apr 4.
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