Jones K R, Weissler M C
Department of Surgery, University of North Carolina, Chapel Hill 27514-7070.
Arch Otolaryngol Head Neck Surg. 1990 Mar;116(3):304-9. doi: 10.1001/archotol.1990.01870030068011.
To determine whether perioperative blood transfusion affected the recurrence rate of squamous cell cancer of the head and neck, we performed a retrospective study of all patients with stage III and IV disease treated surgically at the University of North Carolina, Chapel Hill, between 1983 and 1986. Those who recurred were compared with those who did not in regard to 16 prognostic variables, including whether or not they had received a perioperative blood transfusion. Analyzing each variable separately, five were significantly related to recurrence. These were (1) surgical margin status, (2) stage, (3) presence of pathologically positive nodes, (4) blood transfusion status, and (5) type of treatment. However, because several of these variables were clearly interrelated, the same data were subjected to a multivariate regression analysis specifically designed to identify significant prognostic variables independent of their association with other variables. By this analysis, only margin status and the presence or absence of a blood transfusion were statistically significant predictors of recurrence.
为了确定围手术期输血是否会影响头颈部鳞状细胞癌的复发率，我们对1983年至1986年间在北卡罗来纳大学教堂山分校接受手术治疗的所有III期和IV期疾病患者进行了一项回顾性研究。将复发患者与未复发患者在16个预后变量方面进行比较，包括他们是否接受了围手术期输血。分别分析每个变量，有五个变量与复发显著相关。这些变量是：(1)手术切缘状态，(2)分期，(3)病理检查阳性淋巴结的存在情况，(4)输血状态，以及(5)治疗类型。然而，由于这些变量中有几个明显相互关联，因此对相同的数据进行了多变量回归分析，该分析专门设计用于识别独立于其与其他变量关联的显著预后变量。通过这种分析，只有切缘状态和输血与否是复发的统计学显著预测因素。
