Yamagishi Tomoko, Shimizu Katsuhiko, Nakata Masao, Miyaji Yoshiyuki, Nagai Atsushi, Kanomata Naoki, Moriya Takuya
Dept. of General Thoracic Surgery, Kawasaki Medical School, Japan.
Gan To Kagaku Ryoho. 2012 Oct;39(10):1579-81.
We report a rare case of growing teratoma syndrome(GTS). The patient was a 37-year-old man diagnosed as having a mixed germ cell tumor of the right testis. After resection of the right testis, the patient developed multiple lung metastases and chemotherapy was administered. However, in spite of the normalization of the serum AFP level, the lung metastases continued to increase in size. The lung metastases were successfully resected and pathological examination revealed the diagnosis of a mature teratoma. GTS is defined as an enlarging tumor mass during or after chemotherapy in the case of germ cell tumors, with normalization of the serum AFP. Total surgical resection of the mass yielded a good result. Recognition of this syndrome is important for successful treatment.
我们报告一例罕见的成熟性畸胎瘤综合征（GTS）。患者为一名37岁男性，被诊断为右侧睾丸混合性生殖细胞肿瘤。右侧睾丸切除术后，患者出现多处肺转移并接受了化疗。然而，尽管血清甲胎蛋白（AFP）水平恢复正常，但肺转移灶仍持续增大。肺转移灶成功切除，病理检查确诊为成熟性畸胎瘤。GTS的定义为生殖细胞肿瘤患者在化疗期间或化疗后出现肿瘤肿块增大，而血清AFP恢复正常。对肿块进行完整手术切除取得了良好效果。认识该综合征对成功治疗至关重要。
