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职业功能、精神障碍患者的症状和神经认知:基于社会保障状况的亚组研究。

Occupational functioning, symptoms and neurocognition in patients with psychotic disorders: investigating subgroups based on social security status.

机构信息

Division of Mental Health and Addiction, Psychosis Research Unit, Ullevål Hospital, Oslo University Hospital, P.O. Box 4956, Nydalen, 0424, Oslo, Norway.

出版信息

Soc Psychiatry Psychiatr Epidemiol. 2013 Jun;48(6):863-74. doi: 10.1007/s00127-012-0598-2. Epub 2012 Oct 13.

Abstract

PURPOSE

Reported employment rates for patients with psychosis are low, but vary partly depending on illness phase. Illness-related factors such as neurocognition and negative symptoms are associated with occupational functioning, while external factors may also act as barriers for employment. The current study investigated the relationship between neurocognition, symptoms and employment using a threefold division of employment status: employed, receiving temporary benefits and receiving disability benefits. The latter group was divided into two based on level of social functioning.

METHODS

A total of 155 patients with broad DSM-IV schizophrenia spectrum disorder were assessed with clinical, neurocognitive and social and occupational functioning measures. Group differences were analyzed with ANOVAs and hierarchical regression analysis.

RESULTS

Thirteen percent were employed, 52 % received temporary benefits and 35 % received disability benefits. There were no differences in symptom level and neurocognitive functioning between groups. Among patients on disability benefits, the subgroup with higher social functioning had fewer negative and general symptoms and a trend for better neurocognition compared with those with lower social functioning, thus being more similar to employed patients. Negative symptoms and executive functioning explained 26 % of the variance in social functioning for patients receiving disability benefits.

CONCLUSIONS

The association between neurocognition and employment may not be as strong as previously assumed, due to external factors that may influence this relationship. Patients on disability benefits rated high on social functioning showed similarities with employed patients. This could imply that these patients have some work capacity. This issue needs further investigation.

摘要

目的

精神分裂症患者的就业率较低,但部分就业率因疾病阶段而异。与疾病相关的因素,如神经认知和阴性症状,与职业功能有关,而外部因素也可能成为就业障碍。本研究通过就业状况的三分法(就业、领取临时福利和领取残疾福利),调查了神经认知、症状与就业之间的关系。后者根据社会功能水平进一步分为两组。

方法

共评估了 155 名广泛的 DSM-IV 精神分裂症谱系障碍患者的临床、神经认知和社会及职业功能。采用方差分析和分层回归分析比较组间差异。

结果

13%的患者就业,52%的患者领取临时福利,35%的患者领取残疾福利。各组间症状水平和神经认知功能无差异。在领取残疾福利的患者中,社会功能较高的亚组与社会功能较低的亚组相比,阴性症状和一般症状较少,神经认知功能有改善趋势,与就业患者更为相似。对于领取残疾福利的患者,执行功能和阴性症状解释了社会功能 26%的方差。

结论

由于可能影响这种关系的外部因素,神经认知与就业之间的关联可能并不像之前假设的那样强。社会功能评分较高的残疾福利患者与就业患者具有相似性。这可能意味着这些患者有一定的工作能力。需要进一步研究这个问题。

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