Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan.
Soc Psychiatry Psychiatr Epidemiol. 2013 Jun;48(6):955-63. doi: 10.1007/s00127-012-0600-z. Epub 2012 Oct 11.
To investigate the incidence and cumulative risk of first onset alcohol use disorder (AUD) in a 16-year follow-up among Taiwanese aboriginal populations.
Participants included in this study were cohort subjects free from any AUD at phase 1 survey (n = 428 for DSM-3-R and 451 for DSM-4) of the Taiwan aboriginal study project conducted in 1986-1988. They were reassessed approximately 16 years later, with a response rate of 98.8 %. A Chinese version of the WHO schedules for clinical assessment in neuropsychiatry was employed to assess the lifetime drinking history and AUD.
Age-standardized annual incidence rates of AUD in all groups were 2.26 and 1.75 % according to DSM-3-R and DSM-4, respectively. The overall incidence rates of AUD were comparable to most of other studies in Caucasian populations, but the sex ratios of women to men were higher in this study (1:2-3) than in the latter (1:6). The incidence of AUD was higher with DSM-3-R than with DSM-4 criteria in this study, attributable to the exclusion of physical/psychological harm in DSM-4 alcohol abuse. The cumulative risks of DSM-4 AUD in this study were very high, being 72.2 ± 19.8 for men and 48.7 ± 8.2 for women up to the age of 65 years.
High incidence rates and cumulative risks of AUD in Taiwanese aborigines demand effective prevention strategy.
在一项对台湾原住民 16 年的随访研究中，调查首次出现酒精使用障碍（AUD）的发病率和累积风险。
本研究的参与者是在 1986-1988 年进行的台湾原住民研究项目的第一阶段调查中没有任何 AUD（DSM-3-R 为 428 人，DSM-4 为 451 人）的队列受试者。大约 16 年后对他们进行了重新评估，应答率为 98.8%。采用世界卫生组织神经精神药理学临床评估时间表的中文版本评估终生饮酒史和 AUD。
根据 DSM-3-R 和 DSM-4，所有人群的 AUD 年龄标准化年发病率分别为 2.26%和 1.75%。AUD 的总体发病率与白种人群的大多数其他研究相当，但本研究中女性与男性的性别比例（1:2-3）高于后者（1:6）。与 DSM-4 相比，本研究中使用 DSM-3-R 诊断 AUD 的发病率更高，这归因于 DSM-4 酒精滥用中排除了身体/心理伤害。本研究中 DSM-4 AUD 的累积风险非常高，男性累积风险为 72.2%±19.8%，女性为 48.7%±8.2%，达到 65 岁。
台湾原住民 AUD 的高发病率和累积风险需要有效的预防策略。
