Hozumi Hironao, Fujisawa Tomoyuki, Kuroishi Shigeki, Inui Naoki, Nakamura Yutaro, Suda Takafumi, Chida Kingo
Internal Medicine 2 (Division of Endocrinology & Metabolism), Hamamatsu University School of Medicine, Japan.
Intern Med. 2012;51(20):2933-6. doi: 10.2169/internalmedicine.51.8497. Epub 2012 Oct 15.
We herein report a case of cytomegalovirus (CMV) bronchitis in a 62-year-old woman with polymyositis. She presented with respiratory symptoms and CMV antigenemia while undergoing immunosuppressive therapy with methotrexate (MTX) and prednisolone (PSL). Bronchoscopy was performed, which revealed an ulceration of the left main bronchus. A mucosal biopsy confirmed CMV infection, and the patient was diagnosed with CMV ulcerating bronchitis. The administration of ganciclovir improved the lesion, and the CMV antigenemia disappeared. Endobronchial ulceration should be considered in the differential diagnosis of CMV disease.
我们在此报告一例62岁患有多发性肌炎的女性巨细胞病毒（CMV）支气管炎病例。她在接受甲氨蝶呤（MTX）和泼尼松龙（PSL）免疫抑制治疗期间出现呼吸道症状和CMV抗原血症。进行了支气管镜检查，发现左主支气管有溃疡。黏膜活检证实为CMV感染，该患者被诊断为CMV溃疡性支气管炎。给予更昔洛韦后病变改善，CMV抗原血症消失。在CMV疾病的鉴别诊断中应考虑支气管内溃疡。
