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十七烷酸硬脂酯和相关硬脂烷酸酯作为化妆品用原料的安全性评估。

Safety assessment of stearyl heptanoate and related stearyl alkanoates as used in cosmetics.

机构信息

Cosmetic Ingredient Review, 1101 17th Street NW, Washington, DC 20036, USA.

出版信息

Int J Toxicol. 2012 Sep-Oct;31(5 Suppl):141S-6S. doi: 10.1177/1091581812460408.

DOI:10.1177/1091581812460408
PMID:23064772
Abstract

Stearyl heptanoate is an ester of stearyl alcohol and heptanoic acid that functions in cosmetics as a skin conditioning agent and is in the general class of chemicals called stearyl alkanoates. Stearyl caprylate, stearyl palmitate, stearyl stearate, stearyl behenate, and stearyl olivate are stearyl alkanoates with similar chemical structures, toxicokinetics, and functions in cosmetics. These water-insoluble stearyl alkanoates, when metabolized, yield stearyl alcohol and a corresponding fatty acid. The available information supports the safety of all of the related stearyl alkanoates. The Expert Panel concluded that stearyl heptanoate, stearyl caprylate, stearyl palmitate, stearyl stearate, stearyl behenate, and stearyl olivate are safe in the present practices of use and concentration.

摘要

十七烷酸硬脂醇酯是硬脂醇和十七烷酸的酯,在化妆品中用作皮肤调理剂,属于硬脂烷酸酯类化学品。十七烷酸硬脂醇酯、肉豆蔻酸硬脂醇酯、棕榈酸硬脂醇酯、山嵛酸硬脂醇酯和油醇硬脂酸酯是具有相似化学结构、毒代动力学和在化妆品中功能的硬脂烷酸酯。这些不溶于水的硬脂烷酸酯在代谢时会产生硬脂醇和相应的脂肪酸。现有信息支持所有相关硬脂烷酸酯的安全性。专家小组得出结论,在目前的使用和浓度实践中,十七烷酸硬脂醇酯、肉豆蔻酸硬脂醇酯、棕榈酸硬脂醇酯、山嵛酸硬脂醇酯、油醇硬脂酸酯是安全的。

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