Andonov P, Dundarov S, Bakalov B
Vopr Virusol. 1979 Nov-Dec(6):665-71.
The variants of inactivated vaccine against herpes simplex virus have been developed: 1, 2 and 1 + 2. The first two variants consist of 5 different strains of herpes virus of the appropriate type, and the third variant of their mixture. The strains differ in their antigenic and biological characteristics. Complete inactivation of the virus suspension was achieved by treatment of the vaccine with formalin. Herpes vaccines were used for immunization of 477 patients with frequently relapsing forms of herpes of different localizations. The therapeutic-prophylactic effect of these vaccines indicates their relatively high efficacy: by the end of 9 months favourable results exceeded 95%. Better results were obtained with HSV-1 vaccine. A second cycle of immunization given to some patients resulted in markedly positive effect.
1型、2型以及1+2型。前两种变体由5种相应类型的不同疱疹病毒株组成，第三种变体是它们的混合物。这些毒株在抗原和生物学特性方面存在差异。通过用福尔马林处理疫苗实现了病毒悬液的完全灭活。疱疹疫苗用于477例不同部位频繁复发型疱疹患者的免疫。这些疫苗的治疗预防效果表明其疗效相对较高：到9个月末，良好结果超过95%。HSV-1疫苗取得了更好的效果。对一些患者进行的第二轮免疫产生了明显的积极效果。
