一种无核酸病毒疫苗对口腔单纯疱疹病毒感染的防护作用
Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine.
作者信息
Kitces E N, Morahan P S, Tew J G, Murray B K
出版信息
Infect Immun. 1977 Jun;16(3):955-60. doi: 10.1128/iai.16.3.955-960.1977.
Abstract
The effect of immunization with inactivated herpes virus vaccines, including a vaccine free of all nucleic acid, was investigated in a mouse model system. Protection against oral lesions induced by herpes simplex virus type 1 was demonstrated by several criteria: (i) reduction in the incidence and severity of primary oral lesions; (ii) decrease in acute and latent infection of the regional sensory ganglia; and (iii) protection from viral encephalitis and death. The immune response of mice to the vaccine and to subsequent virus challenge was measured by following serum-neutralizing antibody titers.
摘要
在小鼠模型系统中研究了用灭活疱疹病毒疫苗（包括不含所有核酸的疫苗）进行免疫的效果。通过几个标准证明了对1型单纯疱疹病毒诱导的口腔病变具有保护作用：（i）原发性口腔病变的发生率和严重程度降低；（ii）局部感觉神经节的急性和潜伏感染减少；（iii）预防病毒性脑炎和死亡。通过跟踪血清中和抗体滴度来测量小鼠对疫苗和随后病毒攻击的免疫反应。
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