具有非均匀碱基对的DNA双螺旋中氢键的振动波动。
Vibrational fluctuations of hydrogen bonds in a DNA double helix with nonuniform base pairs.
作者信息
Feng Y, Prohofsky E W
机构信息
Department of Physics, Purdue University, West Lafayette, Indiana 47907.
出版信息
Biophys J. 1990 Mar;57(3):547-53. doi: 10.1016/S0006-3495(90)82570-4.
Abstract
The Green's function technique is applied to a study of breathing modes in a DNA double helix which contains a region of different base pairs from the rest of the double helix. The calculation is performed on a G-C helix in the B conformation with four consecutive base pairs replaced by A-T. The average stretch in hydrogen bonds is found amplified around the A-T base pair region compared with that of poly(dG)-poly(dC). This is likely related to the A-T regions lower stability against hydrogen bond melting. The A-T region may be considered to be the initiation site for melting in such a helix.
摘要
格林函数技术被应用于研究包含与双螺旋其余部分不同碱基对区域的DNA双螺旋中的呼吸模式。计算是在B构象的G-C螺旋上进行的，其中四个连续碱基对被A-T取代。与聚（dG）-聚（dC）相比，发现A-T碱基对区域周围氢键的平均拉伸幅度增大。这可能与A-T区域对氢键解链的稳定性较低有关。A-T区域可被认为是这种螺旋中解链的起始位点。
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