心力衰竭患者骨骼肌的代谢和结构损伤。
Metabolic and structural impairment of skeletal muscle in heart failure.
机构信息
Division of Cardiology, Department of Medicine, Center for Advanced Cardiac Care, Columbia University Medical Center, 622 West 168th Street, PH 10, Room 203, New York, NY, 10032, USA.
出版信息
Heart Fail Rev. 2013 Sep;18(5):623-30. doi: 10.1007/s10741-012-9353-8.
Abstract
Physiologic endurance exercise performance is primarily limited by cardiac function. In patients with heart failure, there is dissociation between cardiac performance and exercise capacity, suggesting a distinct role of abnormal peripheral organ function, including skeletal muscle function. The impact of heart failure upon skeletal muscle and exercise performance will be discussed with a focus on molecular, structural, and functional derangements in skeletal muscle of patients with heart failure.
摘要
生理性耐力运动表现主要受心脏功能限制。心力衰竭患者的心脏功能和运动能力出现分离，表明异常的外周器官功能（包括骨骼肌功能）起着重要作用。本文将重点讨论心力衰竭对骨骼肌和运动表现的影响，以及心力衰竭患者骨骼肌的分子、结构和功能障碍。
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