Fischbach W, Meyer T, Barthel K
Medizinische Poliklinik, University of Würzburg, FRG.
Cancer. 1990 Mar 15;65(6):1321-4. doi: 10.1002/1097-0142(19900315)65:6<1321::aid-cncr2820650612>3.0.co;2-y.
The squamous cell carcinoma (SCC) antigen was determined by radioimmunoassay in the serum of 40 untreated patients with SCC of the oromaxillofacial region. The mean (+/- SEM) serum concentration for these patients (3.8 +/- 0.8 ng/ml) was significantly higher than that of 52 disease-free patients coming to routine postoperative care (1.2 +/- 0.1 ng/ml) and of 74 healthy controls (1.1 +/- 0.07 ng/ml). Using a arbitrary limit of 2.2 ng/ml, pathologic serum levels of SCC were observed in 15 (38%) of 40 untreated patients, whereas only four (7.7%) of 52 tumor-free patients revealed an elevated serum SCC. Serial measurements of SCC were pretherapeutically available in 28 patients as well as during individual therapy and further follow-up. All but one of these patients had a normal serum SCC postoperatively. The authors' results demonstrate that the clinical value of SCC lies mainly in monitoring the course of the disease. Careful follow-up studies should be undertaken to determine whether serial determination of SCC is promising in early prediction of tumor reoccurrence.
采用放射免疫分析法测定了40例未经治疗的口腔颌面部鳞状细胞癌（SCC）患者血清中的SCC抗原。这些患者的血清平均浓度（±标准误）为（3.8±0.8 ng/ml），显著高于52例接受常规术后护理的无病患者（1.2±0.1 ng/ml）和74例健康对照者（1.1±0.07 ng/ml）。以2.2 ng/ml为任意界限，40例未经治疗的患者中有15例（38%）血清SCC水平异常，而52例无肿瘤患者中只有4例（7.7%）血清SCC升高。28例患者在治疗前、个体化治疗期间及进一步随访过程中均进行了SCC的系列测定。除1例患者外，所有这些患者术后血清SCC均正常。作者的结果表明，SCC的临床价值主要在于监测疾病进程。应进行仔细的随访研究，以确定SCC的系列测定在早期预测肿瘤复发方面是否有前景。
