Zöller J, Fiehn W, Mende U, Hotz G
Klinik und Polklinik für Mund-Kiefer-Gesichtschirurgie der Universität Heidelberg.
Dtsch Z Mund Kiefer Gesichtschir. 1990 Jul-Aug;14(4):254-9.
An increased squamous cell carcinoma antigen (SCC) value was found in 33.3% of the patients with carcinomas of the oral cavity. In those patients in whom the tumor recurred, this percentage increased to 75%. Although elevated in 43.4% of the tumor patients, CEA values failed to drop after treatment like the SCC antigens did. Nor was there, in contrast to the SCC antigens, any evident correlation with tumor volume. Thus, pathologic CEA values must be attributed to non-tumor specific concomitant diseases. Ca 19-9, Ca 125 and Ca 15-3 exhibited poor sensitivity. According to the results of our studies the only valid tumor markers are SCC antigens, particularly for monitoring treatment.
在33.3%的口腔癌患者中发现鳞状细胞癌抗原（SCC）值升高。在肿瘤复发的患者中，这一比例增至75%。虽然43.4%的肿瘤患者CEA值升高，但与SCC抗原不同，CEA值在治疗后并未下降。而且，与SCC抗原相反，CEA值与肿瘤体积没有明显相关性。因此，CEA值异常必定归因于非肿瘤特异性的伴随疾病。Ca 19-9、Ca 125和Ca 15-3的敏感性较差。根据我们的研究结果，唯一有效的肿瘤标志物是SCC抗原，尤其是用于监测治疗。
