从动态组合文库中得到的尼古丁合成受体。
A synthetic receptor for nicotine from a dynamic combinatorial library.
机构信息
Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
出版信息
Org Lett. 2012 Nov 2;14(21):5404-7. doi: 10.1021/ol302260n. Epub 2012 Oct 12.
PMID:23067115
Abstract
Designing synthetic receptors that bind biologically relevant guests in an aqueous solution remains a considerable challenge. We now report a new synthetic receptor for nicotine, selected from a dynamic combinatorial library, that binds this guest in water at neutral pH through a combination of hydrophobic and π-π interactions.
摘要
设计能在水溶液中结合生物相关客体的人工合成受体仍然是一个巨大的挑战。我们现在报道了一种从动态组合文库中筛选得到的新型尼古丁人工合成受体，该受体通过疏水作用和π-π相互作用的结合，在中性 pH 的水中能与该客体结合。
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