Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
J Am Chem Soc. 2013 Jun 26;135(25):9222-39. doi: 10.1021/ja402586c. Epub 2013 Jun 11.
Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other. Dynamic combinatorial libraries (DCLs) are powerful tools for discovering the unexpected and have given rise to many fascinating molecules, ranging from interlocked structures to self-replicators. Furthermore, dynamic combinatorial molecular networks can produce emergent properties at systems level, which provide exciting new opportunities in systems chemistry. In this perspective we will highlight some new methodologies in this field and analyze selected examples of DCLs that are under thermodynamic control, leading to synthetic receptors, catalytic systems, and complex self-assembled supramolecular architectures. Also reviewed are extensions of the principles of DCC to systems that are not at equilibrium and may therefore harbor richer functional behavior. Examples include self-replication and molecular machines.
动态组合化学（DCC）是组合化学的一个分支，其中库成员通过彼此交换构建块而不断相互转化。动态组合库（DCL）是发现意外的有力工具，已经产生了许多引人入胜的分子，从互锁结构到自我复制体。此外，动态组合分子网络可以在系统水平上产生涌现性质，为系统化学提供了令人兴奋的新机会。在这篇观点文章中，我们将重点介绍该领域的一些新方法，并分析受热力学控制的 DCL 的选定示例，这些示例导致合成受体、催化系统和复杂的自组装超分子结构。我们还回顾了将 DCC 原理扩展到非平衡系统的情况，这些系统可能具有更丰富的功能行为。示例包括自我复制和分子机器。
